Protoporphyrinogen oxidase is involved in the fluorescence intensity of 5-aminolevulinic acid-mediated laser-based photodynamic endoscopic diagnosis for early gastric cancer

Photodynamic diagnosis (PDD) is an optical imaging technology based on the fundamental biological features of porphyrin metabolism in cancer cells. 5-aminolevulinic acid (5-ALA) is metabolized into protoporphyrin IX (PpIX) in the heme biosynthesis pathway, and it tends to accumulate in tumor cells [1,2]. PpIX emits red fluorescence at around 630  nm when irradiated with a laser of 405 nm wavelength [3]. The utility of PDD has been established in the field of brain tumors and bladder tumors [4–6].

Source: Photodiagnosis and Photodynamic Therapy - February 6, 2018 Category: Laser Surgery Authors: Hiroki Kurumi, Tsutomu Kanda, Koichiro Kawaguchi, Kazuo Yashima, Hiroki Koda, Kumi Ogihara, Kayoko Matsushima, Kazuhiko Nakao, Hiroaki Saito, Yoshiyuki Fujiwara, Mitsuhiko Osaki, Futoshi Okada, Hajime Isomoto Source Type: research