The response surface methodology speeds up the search for optimal parameters in the photoinactivation of E. coli by photodynamic therapy

The Antimicrobial Photodynamic Therapy (a-PDT) is a non-invasive methodology that uses a non-toxic photosensitizer that can be activated by visible light of a specific wavelength, producing reactive oxygen species (ROS) by two different mechanisms [1] (Fig. 1). Peroxides and free radical species, produced by Type I mechanism, result from the interaction between the photosensitizer triplet excited state and the tissue, cells or microorganisms, inducing oxidative processes leading to cell death [2].

Source: Photodiagnosis and Photodynamic Therapy - February 27, 2018 Category: Laser Surgery Authors: Larissa S. Amaral, Eduardo B. Azevedo, Janice R. Perussi Source Type: research