Influence of ALA-mediated photodynamic therapy on secretion of interleukins 6, 8 and 10 by colon cancer cells in vitro

Photodynamic therapy with 5-aminolevulinic acid (ALA-PDT) can be an alternative to surgical resection in cases of pre-neoplastic lesions, early stages of colorectal cancer, colon polyps as well as a palliative treatment of advanced colorectal cancer. Clinical trials have shown the benefits of ALA-PDT in these fields of application [1 –5]. With regard to the immunomodulating effect of PDT, it was found that mainly sublethal PDT influences the expression of interleukins 6 and 10 in tumor and normal tissues and that these changes are involved in the observed effects of PDT on host immune responses [6–10].

Source: Photodiagnosis and Photodynamic Therapy - March 3, 2018 Category: Laser Surgery Authors: Aleksandra Kawczyk-Krupka, Zenon Czuba, Wojciech Latos, Katarzyna Wasilewska, Thomas Verwanger, Barbara Krammer, Aleksander Siero ń Source Type: research