In vitro photodynamic inactivation effects of benzylidene cyclopentanone photosensitizers on clinical fluconazole-resistant Candida albicans

Candida infection is a serious threat to public health that affecting immunocompetent and immunocompromised individuals at different levels of severity worldwide [1]. Within the genus Candida, C. albicans is the most virulent and predominant species in oral mucosal layers, vaginal infections, and invasive bloodstream infections [2,3]. Only a few drugs, such as azoles, polyenes, pyrimidines and echinocandins, are available to treat these types of infections. Fluconazole, in particular, is used extensively in clinical practice because of its high efficacy and reduced toxicity [4].
Source: Photodiagnosis and Photodynamic Therapy - Category: Laser Surgery Authors: Source Type: research