Photodynamic therapy with topical photosensitizers in mucosal and semimucosal areas: review from a dermatologic perspective

Photodynamic therapy (PDT) has been defined a “2-step” procedure based on the interaction between a Photo Sensitizer (PS), a light source with a wavelength specific for that PS and environmental oxygen. PS, after being internalised into cells, activates in response to energy received from the light source and produces cytotoxic species in t he presence of oxygen. These radicals induce a plethora of biochemical intracellular processes that secondarily lead to cell death, either by apoptosis or by necrosis [1–3].

Source: Photodiagnosis and Photodynamic Therapy - April 15, 2018 Category: Laser Surgery Authors: Vieri Grandi, Maurizio Sessa, Luigi Pisano, Riccardo Rossi, Arturo Galvan, Riccardo Gattai, Moira Mori, Luana Tiradritti, Stefano Bacci, Giuliano Zuccati, Pietro Cappugi, Nicola Pimpinelli Source Type: research