Photodynamic therapy does not induce cyclobutane pyrimidine dimers in the presence of melanin

Photodynamic therapy (PDT) is an excellent field treatment modality in dermatology [1 –3]. Cyclobutane pyrimidine dimers (CPDs) are the most frequent DNA changes induced by UV light[4–9]. CPDs were mostly attributed to the effect of UVB. UVA induces cellular effects mostly through reactive oxygen species (ROS), similar to PDT[10,11]. Recent findings suggest that UVA induced ROS c an generate CPDs in the presence of melanin, shedding new light on the role of ROS in CPD induction in melanin containing cells[4].

Source: Photodiagnosis and Photodynamic Therapy - April 24, 2018 Category: Laser Surgery Authors: Shaila Mudambi, Paula Pera, Deschana Washington, Eva Remenyik, Eszter Fidrus, Gal Shafirstein, David Bellnier, Gyorgy Paragh Source Type: research