Evaluation of cross-sectional and longitudinal changes in volumetric bone mineral density in postmenopausal women using single- versus dual-energy quantitative computed tomography

Central quantitative computed tomography (QCT) is increasingly used in clinical trials and practice to assess bone mass or strength and to evaluate longitudinal changes in response to drug treatment. Current studies utilize single-energy (SE) QCT scans, which may be confounded both by the amount of bone marrow fat at baseline and changes in marrow fat over time. However, the extent to which marrow fat changes either underestimate volumetric BMD (vBMD) measurements at baseline or under-/overestimate longitudinal changes in vivo in humans remains unclear.

Source: Bone - April 25, 2018 Category: Orthopaedics Authors: Jad G. Sfeir, Matthew T. Drake, Elizabeth J. Atkinson, Sara J. Achenbach, Jon J. Camp, Amanda J. Tweed, Louise K. McCready, Lifeng Yu, Mark C. Adkins, Shreyasee Amin, Sundeep Khosla Tags: Full Length Article Source Type: research