Genetic testing of long QT syndrome: Should we go back to the future?

In the current issue of the Journal, Giudicessi et  al. [1] perform a critical and comprehensive review of the present status and existing challenges for genetic testing in LQT syndrome. As pointed out by the authors, the advent of high throughput next-generation sequencing technologies, with the consequent “flooding” of data at the DNA level, provide both patients and practicing physicians with plenty of information that sometimes can be difficult to interpret for non-specialized practitioners. In their state of the art review, the authors carefully review the history, mechanisms, and the potential need for reappraisal of some forms of L QT classically seen as monogenic disorders.

Source: Trends in Cardiovascular Medicine - April 17, 2018 Category: Cardiology Authors: Eugenio Cingolani Source Type: research