Hypoxia modulates CCR7 expression in head and neck cancers

Tumours occurring in the anatomical regions of the head and neck are the sixth most common types of cancer worldwide, with over 500,000 new cases and over 350,000 deaths reported every year [1]. A particularly unwelcome hallmark of head and neck cancers is the high incidence of metastasis, particularly to regional lymph nodes. In fact, by the time of diagnosis, nearly half of head and neck cancers have already metastasised to neck lymph nodes and one in ten has metastasised to distant organs [2].

Source: Oral Oncology - April 4, 2018 Category: Cancer & Oncology Authors: Haneen A. Basheer, Edvinas Pakanavicius, Patricia A. Cooper, Steven D. Shnyder, Lisette Martin, Keith D. Hunter, Victoria Vinader, Kamyar Afarinkia Source Type: research