Receiver operating characteristic curve analysis of four Aspergillus-specific IgG assays for the diagnosis of chronic pulmonary aspergillosis
Measurement of Aspergillus-specific IgG is central to the diagnosis of chronic pulmonary aspergillosis (CPA), but manufacturers ’ guidance on test interpretation is based on unpublished data. We performed the first receiver operating characteristic (ROC) area under the curve (AUC) analysis to identify optimal cut-offs for this test in relation to European controls. Aspergillus-specific IgG levels were measured in sera from British adults with CPA and European healthy controls by ImmunoCAP, Immulite, Serion and Bio-Rad assays.
Source: Diagnostic Microbiology and Infectious Disease - Category: Microbiology Authors: Iain D. Page, Caroline Baxter, Christophe Hennequin, Malcolm D. Richardson, Erna van Hoeyveld, Albert W. van Toorenenbergen, David W. Denning Tags: Mycology Source Type: research