Impact of inter-genotypic recombination and probe cross-reactivity on the performance of the Abbott RealTime HCV Genotype II assay for hepatitis C genotyping

This study measured the impact of inter-genotypic recombination and probe cross-reactivity on the performance of the Abbott-RT-HCV assay. 517 samples were genotyped using the Abbott-RT-HCV assay over a one-year period, 34 (6.6%) were identified as HCV genotype 1 without further subtype designation raising the possibility of inaccurate genotyping. These samples were subjected to confirmatory sequencing.

Source: Diagnostic Microbiology and Infectious Disease - January 11, 2018 Category: Microbiology Authors: Siddharth Sridhar, Cyril C.Y. Yip, Jasper F.W. Chan, Kelvin K.W. To, Vincent C.C. Cheng, Kwok-Yung Yuen Tags: Virology Source Type: research