Evaluation of a sequential enzyme immunoassay testing algorithm for Lyme disease demonstrates lack of test independence but high diagnostic specificity

In this study using 3956 control sera, we demonstrated that although this two-tier testing algorithm does significantly improve diagnostic specificity compared with each of the EIAs individually, the WCS EIA and the C6 peptide EIA are not independent tests.

Source: Diagnostic Microbiology and Infectious Disease - February 17, 2018 Category: Microbiology Authors: Gary P. Wormser, Claudia R. Molins, Andrew Levin, Susan C. Lipsett, Lise E. Nigrovic, Martin E. Schriefer, John A. Branda Source Type: research