Determination of the antimicrobial susceptibility and molecular profile of clarithromycin resistance in the Mycobacterium abscessus complex in Japan by variable number tandem repeat analysis

Mycobacterium abscessus complex, including three subspecies —M. abscessus, M. massiliense, and M. bolletii—is resistant to a variety of antibiotics so limited treatment options are available. The susceptibility of these subspecies to antimicrobial agents depends in particular on the erm(41) sequevar and rrl mutations in the 23S rRNA, which are potentiall y related to clarithromycin (CLR) resistance. The purpose of this study was to carry out identification and molecular characterization of these subspecies based on variable number of tandem repeats (VNTR) analysis.
Source: Diagnostic Microbiology and Infectious Disease - Category: Microbiology Authors: Source Type: research