New synergistic combinations of differentiation-inducing agents in the treatment of acute promyelocytic leukemia cells

Acute myeloid leukemia (AML) is a heterogeneous neoplasm characterized by the accumulation of leukemia blasts arrested at various stages of granulocytic and monocytic differentiation [1]. As conventional chemotherapy does not seem to be effective to cure most AML patients, there has been an effort to find new drugs that possess differentiative and apoptotic potentials. Several compounds capable of inducing the differentiation of leukemia cells or cell lines to mature cells in vitro, however, only a few compounds have therapeutic value for leukemia because of their severe side effects or unusually high concentration required [2,3].
Source: Leukemia Research - Category: Hematology Authors: Tags: Research paper Source Type: research