Targeting histone demethylases KDM5A and KDM5B in AML cancer cells: A comparative view

Chromatin organization is a major regulator of cellular processes including DNA replication, transcription, repair and recombination. The organization is controlled by histone modifications such as acetylation, methylation, phosphorylation, sumoylation and ubiquitylation [1 –3]. Among different histone modifications, methylation plays a key role in regulation of gene expression [1,4]. Histones can be methylated on lysine residues in the form of mono, di- or tri- methylation [5]. The histone acceptor (H3 vs H4), the site of lysine residue and the location of the histo ne (coding vs non-coding regions) determines whether methylation leads to transcription activation or repression [2].
Source: Leukemia Research - Category: Hematology Authors: Tags: Research paper Source Type: research