ZFP36L2, a novel AML1 target gene, induces AML cells apoptosis and inhibits cell proliferation

AML1 is a transcription factor, which is expressed in hematopoietic tissues and essential for blood cell development by transactivating target genes known to be critical for myeloid differentiation and function [1]. The chromosomal translocation of transcription factor involving the t(8;21)(q22;q22) is the most frequently recurring cytogenetic abnormalitiy associated with AML, accounting for 10% –12% of AML patients [2,3]. The t(8;21) translocation results in the AML1-ETO fusion protein, which contains only the DNA binding domain of AML1 and almost the full length of ETO.

Source: Leukemia Research - February 27, 2018 Category: Hematology Authors: Jia Liu, Wenting Lu, Shuang Liu, Ying Wang, Saisai Li, Yingxi Xu, Haiyan Xing, Kejing Tang, Zheng Tian, Qing Rao, Min Wang, Jianxiang Wang Tags: Research paper Source Type: research