High frequency of dicentric chromosomes detected by multi-centromeric FISH in patients with acute myeloid leukemia and complex karyotype

A complex karyotype (CK) is found in the bone marrow cells of 10 –12% of patients with acute myeloid leukemia (AML) at the initial cytogenetic evaluation [1]. The incidence increases with the age of the patient [1,2]. CK has been variably defined as harboring at least five abnormalities in different studies [3–6]. CK is traditionally regarded as a poor progno stic factor, and it is strongly associated with poor outcomes particularly in patients showing more than five changes in bone marrow cells [7,8].

Source: Leukemia Research - March 19, 2018 Category: Hematology Authors: Iveta Sarova, Jana Brezinova, Zuzana Zemanova, Sarka Ransdorfova, Karla Svobodova, Silvia Izakova, Lenka Pavlistova, Libuse Lizcova, Adela Berkova, Karolina Skipalova, Lucie Hodanova, Cyril Salek, Anna Jonasova, Kyra Michalova Tags: Research paper Source Type: research