Antihypertensive therapy in nondiabetic chronic kidney disease: a review and update

Hypertension is an important contributor to progression of nondiabetic chronic kidney disease (CKD). Compelling observational evidence indicates that the divergence of blood pressure (BP) away from an ideal range in either direction is associated with a progressive rise in the risk of mortality and cardiovascular and renal disease progression. To date, various clinical trials and meta-analyses examining strict versus less intensive BP control in nondiabetic CKD have not conclusively demonstrated a renal advantage of one BP-lowering approach over another, except in certain subgroups such as proteinuric patients where evidence is circumstantial.

Source: Journal of the American Society of Hypertension - January 21, 2018 Category: Cardiology Authors: Paul J. Der Mesropian, Gulvahid Shaikh, Emmanuelle Cordero Torres, Anum Bilal, Roy O. Mathew Tags: Review Article Source Type: research