Circular RNAs (circRNAs) in cancer

Circular RNAs (circRNAs) are a class of non-coding RNAs that do not have 5 ′ end caps or 3′ end poly (A) tails. There are more than one hundred thousand genes that encode circRNAs. Clinical data show that there are differences in the expression of circRNAs in a variety of diseases, including cancer, suggesting that circRNA has a regulatory effect on some diseases. Furt her studies reveal that circRNA can be used as an endogenous competitive RNA, thereby regulating the proliferation, invasion or other physiological activities of tumor cells.

Source: Cancer Letters - April 3, 2018 Category: Cancer & Oncology Authors: Ruoyu Zhou, Yuwei Wu, Wenxi Wang, Wenjia Su, Yicong Liu, Yumin Wang, Chunmei Fan, Xiaoling Li, Guiyuan Li, Yong Li, Wei Xiong, Zhaoyang Zeng Tags: Mini-review Source Type: research