miR-195 Potentiates the Efficacy of Microtubule-Targeting Agents in Non-Small Cell Lung Cancer

Microtubule-targeting agents (MTAs) are widely used for the treatment of non-small cell lung cancer (NSCLC). The response rate is only ∼25%, mainly attributable to drug resistance. To identify determinants of resistance in NSCLC, we performed a high-throughput screen using a library of miRNA mimics. Here we report that miR-195 synergizes with MTAs to inhibit the growth of NSCLC cells in vitro, that increased expression of miR-195 sensitizes NSCLC cells to MTAs and that repression of miR-195 confers resistance to MTAs.
Source: Cancer Letters - Category: Cancer & Oncology Authors: Tags: Original Articles Source Type: research