Jade family PHD finger 3 (JADE3) increases cancer stem cell-like properties and tumorigenicity in colon cancer

Jade family PHD finger 3 (JADE3) plays a role in inducing histone acetylation during transcription, and is involved in the progression of several human cancers; however, its role in colon cancer remains unclear. Herein, we found that JADE3 was markedly upregulated in colon cancer tissues and significantly correlated with cancer progression, and predicted shorter patient survival. Further, JADE3 was expressed much higher in colon cancer cell lines that are enriched with a stem-like signature. Overexpression of JADE3 increased, while silencing JADE3 reduced cancer stem cell-like traits in colon cancer cells in vitro and in vivo.

Source: Cancer Letters - April 13, 2018 Category: Cancer & Oncology Authors: Yunting Jian, Meng Wang, Yan Zhang, Ruizhang Ou, Ziyuan Zhu, Yangying Ou, Xiangfu Chen, Xin Liang, Yanqing Ding, Libing Song, Xuehu Xu, Wenting Liao Tags: Original Articles Source Type: research