Effect of matrix metalloproteinase 8 inhibitor on resin –dentin bonds

The longevity of resin –dentin bonds is consistently a focus of research in contemporary adhesive dentistry due to the reduction of bond strength over time. The bonded interface is mainly damaged by enzymatic degradation of the collagen matrix [1,2]. Matrix metalloproteinases (MMPs) are present in dentin matrices, which belong to a class of zinc- and calcium-dependent endopeptidases [1,3]. They have been shown to be related with the collagen degradation in the hybrid layers, which may be due to the low-pH environment, the activity of tissue inhibitors of MMPs (TIMPs), and the interaction with cysteine cathepsins.

Source: Dental Materials - February 12, 2018 Category: Materials Science Authors: Qianmin Ou, Ya Hu, Siqi Yao, Yan Wang, Xuefeng Lin Source Type: research