Blocking constitutive activity of GHSR1a in the lateral amygdala facilitates acquisition of conditioned taste aversion

Ghrelin is a circulating peptide hormone promoting feeding and regulating energy metabolism in human and rodents. Ghrelin functions by binding to its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), which are widely distributed throughout the brain including the amygdala, a brain region important for regulating valenced behavior, such as aversion. Interestingly, GHSR1a was once characterized by highly constitutive, ligand-independent activity. However, the physiological importance of such ligand-independent signaling on aversive memory processing has not been tested yet.

Source: Neuropeptides - December 5, 2017 Category: Neuroscience Authors: Nan Li, Ge Song, Yaohui Wang, Qianqian Zhu, Fubing Han, Chonghui Zhang, Yu Zhou Source Type: research