Antinociceptive profiles and mechanisms of centrally administered oxyntomodulin in various mouse pain models

In the present study, the antinociceptive profiles of oxyntomodulin were examined in ICR mice. Oxyntomodulin administered intrathecally (i.t.) and intracerebroventricularly (i.c.v.) (from 1 to 5 μg/5μl) showed an antinociceptive effect in a dose-dependent manner as measured in the acetic acid-induced writhing test. Moreover, cumulative response time of nociceptive behaviors induced by intraplantar formalin injection was reduced by i.t. or i.c.v. treatment with oxyntomodulin during the sec ond, but not the first phase.
Source: Neuropeptides - Category: Neuroscience Authors: Source Type: research