Role of orexins in the central and peripheral regulation of glucose homeostasis: Evidences & mechanisms

Orexins (A& B), neuropeptides of hypothalamic origin, act through G-protein coupled receptors, orexin 1 receptor (OX1R) and orexin 2 receptor (OX2R). The wide projection of orexin neurons in the hypothalamic region allows them to interact with the other neurons and regulate food intake, emotional status, sleep wake cycle and energy metabolism. The autonomic nervous system plays an important regulatory role in the energy metabolism as well as glucose homeostasis. Orexin neurons are also under the control of GABAergic neurons.
Source: Neuropeptides - Category: Neuroscience Authors: Tags: News and reviews Source Type: research