Effects of centrally administered glucagon-like peptide-2 on blood pressure and barosensitive neurons in spontaneously hypertensive rats

The central administration of glucagon-like peptide-2 (GLP-2) decreases blood pressure in rats. In the present study, we investigated the hypotensive effects of GLP-2 using spontaneously hypertensive rats (SHRs), an animal model of hypertension. The central administration of GLP-2 (0.6  μg) decreased mean arterial pressure (MAP) in SHRs (−24.1 ± 4.5%; P  0.05), whereas GLP-2 (6 μg) decreased MAP in WKY rats (−23.5 ± 4.2%; P 
Source: Neuropeptides - Category: Neuroscience Authors: Source Type: research