PACAP and VIP regulate hypoxia-inducible factors in neuroblastoma cells exposed to hypoxia

Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are two related peptides acting as neurotransmitters/neuromodulators in central and peripheral nervous system. They are also involved in cancer showing a controversial role. Particulary, they are implicated in neuroblastoma differentiation (NB). This pediatric tumor can evolve to a malignant metastatic disease or spontaneously regress towards a benign form, known as ganglioneuroblastoma/ganglioneuroma.

Source: Neuropeptides - April 17, 2018 Category: Neuroscience Authors: Grazia Maugeri, Agata Grazia D'Amico, Daniela Maria Ras à, Salvatore Saccone, Concetta Federico, Sebastiano Cavallaro, Velia D'Agata Source Type: research