High-throughput determination of valproate in human samples by modified QuEChERS extraction and GC-MS/MS

Valproate is widely prescribed despite the emergence of newly developed medications for epilepsy [1 –4], but it is used in misuse or suicide cases [5–7]. Rapid determinations for valproate in human samples are required for quick diagnosis and effective treatment of intoxication cases. Only small amounts of samples could be available in some forensic cases; its sensitive identification and quan tification methods are thus needed, although therapeutic and toxic concentrations of valproate are quite high in human samples.

Source: Legal Medicine - January 16, 2018 Category: Forensic Medicine Authors: Shun Mizuno, Xiao-Pen Lee, Masaya Fujishiro, Takaaki Matsuyama, Miho Yamada, Yuki Sakamoto, Maiko Kusano, Kei Zaitsu, Chika Hasegawa, Iwao Hasegawa, Takeshi Kumazawa, Akira Ishii, Keizo Sato Source Type: research