Cytomegalovirus sequence variability, amplicon length, and DNase-sensitive non-encapsidated genomes are obstacles to standardization and commutability of plasma viral load results

Cytomegalovirus represents a persisting challenge to transplant patients due to its direct and indirect effects decreasing graft and patient survival [1 –4]. Significant progress has been made in the clinical management of CMV replication post-transplantation through the concerted action of stratifying CMV risk according to CMV IgG serostatus of donor and recipient pairs, implementing prophylactic or preemptive antiviral strategies, and developing consensus definitions and guidelines [5–7]. Central to current medical practice is the sensitive and specific detection and quantification of CMV replication for clinical studies as well as for therapy decisions [7,8].
Source: Journal of Clinical Virology - Category: Virology Authors: Source Type: research