Exercise and Chemotherapy-Induced Amenorrhea

Chemotherapy-induced amenorrhea (CIA) is the temporary or permanent loss of menses experienced by premenopausal women undergoing chemotherapy treatment for cancer. Two possible mechanisms through which chemotherapy induces CIA have been identified: systemic endothelial dysfunction, resulting in decreased blood flow to the ovaries, and increased oxidative stress within the ovaries, both of which are proposed to lead to apoptosis of follicles. Endothelial dysfunction in ovarian arteries in women undergoing or who have undergone chemotherapy treatment is characterized by prothrombotic changes and thickening of the vascular wall.

Source: Medical Hypotheses - April 25, 2018 Category: Biomedical Science Authors: Katlynn M. Mathis, Kathleen M. Sturgeon, Renate M. Winkels, Joachim Wiskemann, Nancy I. Williams, Kathryn Schmitz Source Type: research