The impact of sex steroid agonists and antagonists on folliculogenesis in the neonatal porcine ovary via cell proliferation and apoptosis

The objective of the study was to examine the effects of androgen and estrogen agonists or antagonists on the follicle formation, ovarian cell proliferation and apoptosis as well as plasma steroid concentration in neonatal pigs. Piglets were injected with testosterone propionate (TP, 20  mg/kg bw), flutamide (FLU, 50 mg/kg bw), 4-tert-octylphenol (OP, 100 mg/kg bw), ICI 182,780 (ICI, 400 μg/kg bw), methoxychlor (MXC, 100 mg/kg bw) or corn oil (CTR, controls) between postnatal Days 1 and 10 (n = 4/group).

Source: Theriogenology - February 9, 2018 Category: Genetics & Stem Cells Authors: Katarzyna Knapczyk-Stwora, Malgorzata Grzesiak, Renata E. Ciereszko, Elzbieta Czaja, Marek Koziorowski, Maria Slomczynska Source Type: research