Expression patterns and role of SDF-1/CXCR4 axis in boar spermatogonial stem cells

The signaling of chemokine stromal cell-derived factor (SDF)-1 and its receptor C-X-C motif chemokine receptor 4 (CXCR4) is involved in the cellular proliferation, survival, and migration of various cell types. Although SDF-1/CXCR4 has been implicated in the maintenance of the spermatogonial population during mouse testis development, their expression patterns and functions in boar testis remain unclear. In the present study, the expression pattern of SDF-1 and CXCR4 was determined during pre-pubertal and post-pubertal stage boar testes and in  vitro cultured porcine spermatogonial stem cells (pSSCs).
Source: Theriogenology - Category: Genetics & Stem Cells Authors: Source Type: research