Robust and efficient pharmacokinetic parameter non-linear least squares estimation for dynamic contrast enhanced MRI of the prostate

To describe an efficient numerical optimization technique using non-linear least squares to estimate perfusion parameters for the Tofts and extended Tofts models from dynamic contrast enhanced (DCE) MRI data and apply the technique to prostate cancer.

Source: Magnetic Resonance Imaging - December 23, 2017 Category: Radiology Authors: Soudabeh Kargar, Eric A. Borisch, Adam T. Froemming, Akira Kawashima, Lance A. Mynderse, Eric G. Stinson, Joshua D. Trzasko, Stephen J. Riederer Tags: Original contribution Source Type: research