The prognostic value of proton magnetic resonance spectroscopy in term newborns treated with therapeutic hypothermia following asphyxia

In their recent manuscript Sijens et al. describe MRS of asphyxiated neonates treated by therapeutic hypothermia in association with outcome [1]. They conclude that lactate levels had no relationship with outcome. This is in sharp contrast with our recent findings. ROC analysis with an area under the curve (AUC) of 0.89 indicated that a Lac/NAA ratio of>0.40 was associated with an adverse outcome [2]. By looking at the 1H-MR spectra of our recent fullterm infant with severe perinatal asphyxia examined on the 3rd day after birth (Fig.
Source: Magnetic Resonance Imaging - Category: Radiology Authors: Tags: Letter to the Editor Source Type: research