The need for patient-tailored dosing of baclofen in future clinical trials ☆

We enjoyed reading Thompson et al. ’s systematic review of baclofen dosing protocols for treating alcohol use disorder (AUD) in observational studies. The most recent double-blind randomized clinical trials on baclofen for treating AUD have had disappointing results, even at high doses (Beraha et al., 2016). This has led some autho rs to conclude that the drug should not be used. Based on their review of observational studies, Thompson et al. rightfully concluded that it was impossible to associate dose with effectiveness because of good outcomes reported at both low and high doses.
Source: European Neuropsychopharmacology - Category: Psychiatry & Psychology Authors: Source Type: research