SWI/SNF Protein Expression Status in Fumarate Hydratase-deficient Renal Cell Carcinoma: Immunohistochemical Analysis of 32 Tumors from 28 Patients

Fumarate hydratase-deficient renal cell carcinoma (FH-RCC) is a rare, aggressive RCC type, originally described in the setting of hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome which is defined by germline FH gene inactivation. Inactivation of components of the SWI/SNF chromatin remodelling complex is involved in renal medullary carcinoma (SMARCB1/INI1 loss), clear cell RCC (PBRM1 loss) and in subsets of dedifferentiated RCC of clear cell, chromophobe and papillary types (loss of different SWI/SNF components).

Source: Human Pathology - April 21, 2018 Category: Pathology Authors: Abbas Agaimy, Mahul B. Amin, Anthony J. Gill, Bernt Popp, Andr é Reis, Daniel M Berney, Cristina Magi-Galluzzi, Mathilde Sibony, Steven C. Smith, Saul Suster, Kiril Trpkov, Ondřej Hes, Arndt Hartmann Tags: Original contribution Source Type: research