Protective effect of the riboflavin-overproducing strain lactobacillus plantarum CRL 2130 on intestinal mucositis in mice

Mucositis refers to mucosal inflammation and frequently occurs as a side effect of cancer treatments such as chemotherapy and radiotherapy. Fluorouracil (5-FU) is one of the most prescribed chemotherapeutic agents, due to its ability to interrupt DNA (deoxyribonucleic acid) synthesis and to stimulate cell apoptosis [1]. However, one important limitation of 5-FU use is that this drug is not cell specific since it exerts cytotoxity not only on cancerous cells, but also on other fast reproducing ones [2].
Source: Nutrition - Category: Nutrition Authors: Source Type: research