Involvement of central nervous system in adult patients with acute myeloid leukemia: Incidence and impact on outcome

Incidence and effect on outcome of central nervous system (CNS) involvement in adult patients with acute myeloid leukemia (AML) is not clearly defined. To address this issue, 103 consecutive adult patients with newly diagnosed AML, regardless of neurologic symptoms, were submitted to a routine explorative lumbar puncture. Cerebrospinal fluid (CSF) samples were collected from 65 males and 38 females. All 103 CSF samples were examined by conventional cytology (CC) whereas 95 (92%) also by flow cytometry (FCM).

Source: Seminars in Hematology - February 21, 2018 Category: Hematology Authors: Maria Ilaria Del Principe, Francesco Buccisano, Stefano Soddu, Luca Maurillo, Mariagiovanna Cefalo, Alfonso Piciocchi, Maria Irno Consalvo, Giovangiacinto Paterno, Chiara Sarlo, Eleonora De Bellis, Annagiulia Zizzari, Gottardo De Angelis, Daniela Fraboni, Tags: Review Source Type: research