Setting the stage for individualized therapy in hemophilia: What role can pharmacokinetics play?

Replacement therapy with clotting factor concentrates (CFC) is the mainstay of treatment in hemophilia. Its widespread application has led to a dramatic decrease in morbidity and mortality in patients, with concomitant improvement of quality of life. However, dosing is challenging and costs are high. This review discusses benefits and limitations of pharmacokinetic (PK)-guided dosing of replacement therapy as an alternative for current dosing regimens. Dosing of CFC is now primarily based on body weight and based on its in vivo recovery (IVR).

Source: Blood Reviews - February 4, 2018 Category: Hematology Authors: H.C.A.M. Hazendonk, I. van Moort, R.A.A. Math ôt, K. Fijnvandraat, F.W.G. Leebeek, P.W. Collins, M.H. Cnossen, for the OPTI-CLOT study group Tags: Review Source Type: research