Nephrotoxicity of piperacillin-tazobactam combined with vancomycin: Should it be a concern?

Acute Kidney Injury (AKI) has been reported in 8% to 60% of hospitalized patients and is associated with increased morbidity and mortality [1]. Nephrotoxic drugs such as angiotensin-converting enzyme inhibitors (ACE-Is), angiotensin receptor blocking agents (ARBs), nonsteroidal anti-inflammatory drugs, amphotericin B, aminoglycosides and acyclovir are among the most common causes of AKI in hospitalized patients [2]. Although the use of potentially nephrotoxic drugs is inevitable in most cases, drug-induced nephrotoxicity is frequently overlooked as a preventable cause of AKI.

Source: International Journal of Antimicrobial Agents - April 9, 2018 Category: Drugs & Pharmacology Authors: Cafer Balc ı, Ömrüm Uzun, Mustafa Arıcı, Sibel Aşçıoğlu Hayran, Deniz Yüce, Serhat Ünal Source Type: research