Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer

The concept of nonsurgical laryngeal preservation was demonstrated as an alternative to total laryngectomy (TL) for patients with locally advanced laryngeal cancer in the landmark “Department of Veterans Affairs (VA) Laryngeal Cancer Study“ (VALCS) in 1991 [1]. While advocating a general role for nonsurgical therapy for advanced laryngeal cancer, the VA study did suggest that this approach was less successful for patients with the most advanced (but resectable) disease, s ince 56% of patients with T4 disease required salvage laryngectomy compared with 29% with smaller tumors.

Source: Oral Oncology - February 11, 2018 Category: Cancer & Oncology Authors: Mona Kamal, Sweet Ping Ng, Salman A. Eraj, Crosby D. Rock, Brian Pham, Jay A. Messer, Adam S. Garden, William H. Morrison, Jack Phan, Steven J. Frank, Adel K. El-Naggar, Jason M. Johnson, Lawrence E. Ginsberg, Renata Ferrarotto, Jan S. Lewin, Katherine A. Source Type: research