Overexpression of PIK3CA in head and neck squamous cell carcinoma is associated with poor outcome and activation of the YAP pathway

We have shown that in HNSCC tumors high expression of PIK3CA is a poor prognosis factor. Increased gene expression leads to augmented level of the p110 α protein. This correlates with a decrease in the phosphorylation of the YAP transcription regulator (YAP-P) enabling its translocation to the nucleus and the transcription of YAP-target genes that promote different processes involved in tumorigenesis. The connection between increased PIK3CA expres sion and YAP nuclear translocation has not been established yet at the molecular level (dotted red arrow).

Source: Oral Oncology - March 3, 2018 Category: Cancer & Oncology Authors: Ram ón García-Escudero, Carmen Segrelles, Marta Dueñas, María Pombo, Claudio Ballestín, Marina Alonso-Riaño, Pablo Nenclares, Roberto Álvarez-Rodríguez, Gregorio Sánchez-Aniceto, Ana Ruíz-Alonso, José Luis López-Cedrún, Jesús M. Paramio, Cor Source Type: research