Discovering transcriptional signatures of disease for diagnosis versus mechanism

Nature Reviews Immunology 18, 289 (2018). doi:10.1038/nri.2018.26 Authors: Julie G. Burel & Bjoern Peters Transcriptional signatures of disease can be used for diagnosis or to gain insight into disease mechanisms. This Comment article discusses the different sets of criteria that should be considered for the optimal design of investigations addressing these two purposes, using examples from the study of tuberculosis.
Source: Nature Reviews Immunology - Category: Allergy & Immunology Authors: Tags: Comment Source Type: research