PA28 γ acts as a dual regulator of IL-6 and CCL2 and contributes to tumor angiogenesis in oral squamous cell carcinoma

PA28 γ promotes tumor development and progression and is suggested to play a role in tumor angiogenesis, but the molecular mechanisms have not been investigated. Here, we found that PA28γ enhanced the ability of OSCC cells to promote the migration, invasion, and tube formation of HUVECs and promoted tu mor-induced angiogenesis in xenograft mice models in vivo. Then, a mechanism study revealed that the expression and secretion of IL-6 and CCL2 were dependent on PA28γ expression. Furthermore, blocking IL-6 or CCL2 or the transcription factor NF-κB induced the inhibition of tube formation in HUVECs co-cultured with PA28γ-overexpression OSCC cell supernatants.

Source: Cancer Letters - April 24, 2018 Category: Cancer & Oncology Authors: Sai Liu, Dongjuan Liu, Xin Zeng, Jiongke Wang, Jiajia Liu, Junxin Cheng, Kexin Lei, Hetian Bai, Ning Ji, Min Zhou, Lu Jiang, Hongxia Dan, Jing Li, Qianming Chen Tags: Original Articles Source Type: research