Knockdown of TGF- β1 expression in human umbilical cord mesenchymal stem cells reverts their exosome-mediated EMT promoting effect on lung cancer cells

In this study, we found that human umbilical cord MSC-conditioned medium (MSC-CM) promotes EMT, invasion, and migration, yet inhibits proliferation and promotes apoptosis of lung cancer cells. The EMT-promoting effect of MSCs was mediated by exosomes derived from MSCs (MSC-exo) and eliminated by inhibiting exosome release.

Source: Cancer Letters - April 24, 2018 Category: Cancer & Oncology Authors: Xiaoyin Zhao, Xue Wu, Manqing Qian, Yuxian Song, Dongliang Wu, Wen Zhang Tags: Original Articles Source Type: research