Micellar solubilisation enhances the anti-inflammatory activities of curcumin and boswellic acids in rats with adjuvant-induced arthritis

Using advanced micellation technology, stable solubilisates of curcumin and boswellia extracts with markedly enhanced bioavailability were prepared. The drugs were given daily for 3 weeks, starting from the day of Freund complete adjuvant innoculation. Solubilized curcumin showed a reduction in paw volume, tumor necrosis factor- α, interleukin-6 and C-reactive protein, myloperoxidase and lipid peroxidation markers as well as an increase in total antioxidant capacity, an effect which wass equivalent to diclofenac.

Source: Nutrition - April 23, 2018 Category: Nutrition Authors: Mohamed T. Khayyal, Rania M. El-Hazek, Walaa A. El-Sabbagh, Jan Frank, Dariush Behnam, Mona Abdel-Tawab Source Type: research