Impaired Cav-1 expression in SSc mesenchymal cells upregulates VEGF signaling: a link between vascular involvement and fibrosis

Conclusions:
During SSc, the lower levels of Cav-1 may contribute to the pathogenesis of fibrosis via an upregulation of the VEGF signaling in perivascular cells which are shifted to a profibrotic phenotype.

Source: Fibrogenesis and Tissue Repair - September 15, 2014 Category: Biomedical Science Authors: Paola CiprianiPaola Di BenedettoDaria CapeceFrancesca ZazzeroniVasiliki LiakouliPiero RuscittiIlenia PantanoOnorina BerardicurtiFrancesco CarubbiEdoardo AlesseRoberto Giacomelli Source Type: research