Recruited T cells promote the bladder cancer metastasis via up-regulation of the estrogen receptor β/IL-1/c-MET signals

Clinical data indicates that T cells can be recruited to bladder cancer (BCa) tumors, yet the impact of T cells on BCa progression remains unclear. In the present study, we found that T cells were recruited more to BCa tissues than to the surrounding normal bladder tissues. Results from an in vitro co-culture system also found that BCa recruited more CD4+ T cells than did normal bladder cells. The recruiting of T cells to BCa tissues may increase the proliferation and invasion of BCa cells. Mechanistic studies revealed that infiltrating T cells stimulate BCa estrogen receptor beta (ER β) signaling and consequently increase the expression of MET proto-oncogene, receptor tyrosine kinase (c-MET), through either direct binding to its promoter or via modulation of IL-1 expression.

Source: Cancer Letters - April 20, 2018 Category: Cancer & Oncology Authors: Le Tao, Jianxin Qiu, Spencer Slavin, Zhenyu Ou, Zhihong Liu, Jifu Ge, Elizabeth A. Guancial, Edward M. Messing, Chawnshang Chang, Shuyuan Yeh Tags: Original Articles Source Type: research