[Articles] Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study

Cerebral tryptophan metabolism, which is known to affect Mycobacterium tuberculosis growth and CNS inflammation, is important for the outcome of tuberculous meningitis. CSF tryptophan concentrations in tuberculous meningitis are under strong genetic influence, probably contributing to the variable outcomes of tuberculous meningitis. Interventions targeting tryptophan metabolism could improve outcomes of tuberculous meningitis.

Source: The Lancet Infectious Diseases - January 23, 2018 Category: Infectious Diseases Authors: Arjan van Laarhoven, Sofiati Dian, Ra úl Aguirre-Gamboa, Julian Avila-Pacheco, Isis Ricaño-Ponce, Carolien Ruesen, Jessi Annisa, Valerie A C M Koeken, Lidya Chaidir, Yang Li, Tri Hanggono Achmad, Leo A B Joosten, Richard A Notebaart, Rovina Ruslami, Mih Tags: Articles Source Type: research