Potential leukemic cells engraftment after hematopoietic stem cell transplantation from unrelated donors with undiagnosed chronic leukemia

Donor related neoplasms are a potential complication of treatment strategies involving stem cell transplantation. Although mechanisms for detection of short-term complications after these procedures are well developed, complications with delayed onset, notably transmission of chronic diseases such as chronic myeloid leukemia (CML), have been difficult to assess. Consequently, we studied the potential of human CML cells to engraft hematopoietic tissues after intravenous implantation in mice.

Source: Transplantation Proceedings - April 17, 2018 Category: Transplant Surgery Authors: Mi łosz P. Kawa, Bartłomiej Baumert, Zofia Litwińska, Michał Gniot, Ewa Pius-Sadowska, Dorota Rogińska, Krzysztof Lewandowski, Barbara Zdziarska, Bogusław Machaliński Source Type: research